A blog disproving the supernatural, co-run by NEET teenager Yuuta Gamon and his enthusiastic best friend Ryouka Narusawa, becomes the catalyst that would bring together a group of people who supposedly have nothing to do with each other. These individuals include high school fortune teller Miyuu Aikawa, who joins Yuuta to work on the blog; realist Sarai Hashigami, who is stunned when tragedy strikes his family; doujin artist Ririka Nishizono, who has an uncanny ability to predict the future with her art; black magic practitioner and local curse expert Aria Kurenaino and her ghostly friend; Shun Moritsuka, a seemingly childish otaku detective; and reporter Touko Sumikaze. As this unlikely group, bound only by the strings of fate, find their way to each other, they are confronted with murder and other events that are shrouded by the presence of the supernatural. They must band together to solve the mysteries interlacing the city and their lives.

With a cartload of fur pelts in tow, traveling merchant Kraft Lawrence stops by the village of Pasloe. According to local folklore, centuries ago, one of the villagers made a promise with the wolf deity Holo, who swore to bless Pasloe with bountiful harvests of wheat. Yet, as time passed, such stories became little more than relics of the past. After quickly finishing his business in the village, Lawrence sets out to his next destination. His journey, however, takes an unexpected turn when he discovers a nude, animal-eared girl sleeping among his pelts. Even more surprisingly, the youthful-looking woman claims to be Holo—the wolf of legend. Holo wishes to return to her hometown in the north, and though their first encounter is rocky, she convinces Lawrence to accompany her on her travels. In return, she vows to earn her keep, using her quick wits and lifetime of experience to help her newfound companion in his dealings. As they continue their journey, Lawrence and Holo take advantage of whatever economic opportunities they come across, often landing in situations that put both their business skills and their relationship to the test.

Hajime Ichinose's ordinary life is in for a change when a transcendent being named J.J Robinson hands her a small book called NOTE—a device which transforms her into one of the Gatchaman, the legendary protectors of Tachikawa City. Stressing that the existence of their group must remain a secret, fellow Gatchaman Sugane Tachibana takes Hajime to their base of operations, where Paiman, the panda-like alien leader of the Gatchaman, reveals their purpose: to eliminate aliens that pose a danger to humanity. These existential threats, called MESS, are becoming increasingly dangerous, destroying everything they touch. Now it's up to the Gatchaman and their new recruit to stop them before the world is engulfed in chaos.

Shinichi Chiaki is quickly making a name for himself as the principal conductor of the revitalized Roux-Marlet Orchestra, and Megumi Nodame Noda has made leaps and bounds as a pianist at the Conservatoire de Paris. However, tensions mount between the two as Nodame feels left behind by Chiaki's growing success and his close friendship with legendary piano prodigy Rui Son. Disregarding her teacher Professor Charles Auclair's advice, Nodame enters another piano competition in an attempt to jumpstart her own performance career. Meanwhile, those around Chiaki and Nodame are at their own crossroads. Rui begins to doubt herself after hearing Nodame's playing and being denied tutelage from Auclair; Maestro Franz von Stresemann faces the reality of his mortality; pianists Yunlong Li and Tatiana Vishneva feverishly prepare for a competition, while the latter also struggles with her growing feelings for oboist and fellow student Yasunori Kuroki. As Chiaki, Nodame, and their friends continue on their respective journeys, they must not only strive to stay true to themselves, but also remember where it all started.