Youkai Academy is a seemingly normal boarding school, except that its pupils are monsters learning to coexist with humans. All students attend in human form and take normal academic subjects, such as literature, gym, foreign language, and mathematics. However, there is one golden rule at Youkai Academy—all humans found on school grounds are to be executed immediately! Tsukune Aono is an average teenager who is unable to get into any high school because of his bad grades. His parents inadvertently enroll him into Youkai Academy as a last-ditch effort to secure his education. As Tsukune unknowingly enters this new world, he has a run-in with the most attractive girl on campus, Moka Akashiya. Deciding to stay in the perilous realm in order to further his relationship with Moka, he does not realize that beneath her beauty lies a menacing monster—a vampire. Rosario to Vampire is a supernatural school comedy that explores Tsukune's romantic exploits, experiences, and misadventures with a bevy of beautiful but dangerous creatures.

Spirits are otherworldly entities with immense power, capable of creating spatial quakes whenever they appear. One way of dealing with them is through brute force and killing them... or making them fall in love and sealing their powers. Having sealed three Spirits, Shidou Itsuka continues his mission with Ratatoskr in locating more spirits and dating them, to ensure the world's safety from further destruction. However, this time around, their problems will not be limited to Spirits as a more imposing threat seems to have noticed their activities.

After his relationship with Eris Boreas Greyrat reaches new heights, Rudeus Greyrat is ecstatic. Unfortunately, his joy is short-lived, as Eris suddenly abandons him to embark on her own journey. Believing that Eris has lost all interest in him, a heartbroken and depressed Rudeus sets forth to the Northern Territories. With his sole goal being to locate his mother on the vast continent, Rudeus wonders if persisting through daily life is worth the pain, falling into a robotic routine as he endlessly ruminates on his lost love. However, the dangers of the North soon prove that one cannot survive with a dulled mind. While on a quest with the party Counter Arrow, with whom he recently became acquainted, Rudeus has a brush with death—an experience that forces him to finally snap out of his despair. With his newfound teammates, Rudeus rediscovers the pleasure of daily adventuring and moves forward with his original goal of living his second lease on life to the fullest.

Holo is a powerful wolf deity who is revered in the small town of Pasloe for blessing the annual harvest. Yet as years go by and the villagers become more self-sufficient, Holo has been reduced to a mere folktale. When a traveling merchant named Kraft Lawrence stops at the settlement, Holo offers to become his business partner if he takes her to her northern home of Yoitsu. The savvy trader recognizes Holo's unusual ability to evaluate a person's character and accepts her proposition. Now in the possession of both sharp bargaining skills and a charismatic negotiator, Lawrence inches closer to his goal of opening his own shop. However, as Lawrence travels the countryside with Holo in search of economic opportunities, he begins to realize that his aspirations are slowly morphing into something unexpected.