When Gintoki apprehends a movie pirate at a premiere, he checks the camera's footage and finds himself transported to a bleak, post-apocalyptic version of Edo, where a mysterious epidemic called the White Plague has ravished the world's population. It turns out that the movie pirate wasn't a pirate after all—it was an android time machine, and Gintoki has been hurtled five years into the future! Shinpachi and Kagura, his Yorozuya cohorts, have had a falling out and are now battle-hardened solo vigilantes and he himself has been missing for years, disappearing without a trace after scribbling a strange message in his journal. Setting out in the disguise given to him by the android time machine, Gintoki haphazardly reunites the Yorozuya team to investigate the White Plague, and soon discovers that the key to saving the future lies in the darkness of his own past. Determined to confront a powerful foe, he makes an important discovery—with a ragtag band of friends and allies at his side, he doesn't have to fight alone.

A.D. 2016, the foundations of humanity have been incinerated by the Mage King Solomon. Chaldea, a secret mages organization with the mission to preserve humanity's future, foresaw mankind's extinction in 2015. Thus commenced the operation to repair the Singularities in history caused by Holy Grails dispersed across time and space—Operation Grand Order. Using the Rayshift time travel technology, Chaldea's last master Ritsuka Fujimaru and his demi-servant Mash Kyrielight have traveled to and resolved six Singularities. Now, they depart for their most dangerous destination yet: a civilization in the Age of Gods, B.C. 2655 Mesopotamia. Ritsuka and Mash soon discover that Demonic Beasts roam the land, attacking people and towns. Amidst chaos and terror lies humanity's last defense—Uruk, a fortress city that acts as the frontline for the battle against the beasts. The battlefront is commanded by none other than King Gilgamesh, the King of Heroes, who sought aid from Heroic Spirits and took on the role of a mage to protect his city. Along with Gilgamesh and the summoned servants, Ritsuka and Mash must protect Uruk against the magical beasts' onslaught and defeat the Three Goddess Alliance who aims to eradicate humankind; all the while, a greater threat looms over Uruk, preparing for its awakening.

Using her wit and vast knowledge of medicines and poisons alike, Maomao played a pivotal role in solving a series of mysteries and conspiracies that plagued the imperial court. Having recently come to terms with the secrets of her parents, she returns to fulfill her normal duties on behalf of the emperor's highest-ranking consorts. Maomao also works alongside the eunuch Jinshi to better the consorts' many ladies-in-waiting, including helping them learn to read. However, with the arrival of a merchant caravan comes a new wave of intrigue. A pattern of strange coincidences involving the visitors and their wares unsettles Maomao, driving her to investigate the puzzling circumstances behind the convoy. As dangers from both outside and within threaten the balance between the imperial concubines, Maomao continues to utilize her cunning and medical expertise to keep the women safe from harm.

When Myne learns that the Holy Church is in need of mana for their relics, she sees it as her chance to be cured of her life-threatening mana disorder. After seeing their bountiful library, she throws herself headfirst into the Church's grasp and begs to join their order. In exchange for her service and her unusually bountiful supply of mana, Myne is given the blue robes of a noble-born apprentice priestess, despite being a commoner. To Myne, all this talk of mana and nobility is trivial, as she now has access to an unlimited supply of books! As Myne transitions into the next phase of her life in this new world, she soon learns that achieving her dream has come at a heavy cost. Noble society is severe, unforgiving, and fueled by politics and neglect. She must now deal with the class conflict between the noble-born blue robes and the common-born grey robes, the High Priest's attempts to oust her, and constant behavioral issues from her new retainers. With the help of her family, friends, and the enigmatic Head Priest whose loyalties and motives remain unknown, Myne seeks to overcome these obstacles and continue on the path to becoming her ideal self—the ultimate librarian!