​On the island of Regalo, a group of supernaturally powered mafia-like protectors called the Arcana Famiglia safeguard the people from any who would harm them. The members of their organization, having made contracts with tarot cards, each possess different abilities, such as overwhelming strength, invisibility, or the power to see into someone's heart. Mondo, their leader and the Papa of their family, announces at his birthday party that he will be retiring soon. He plans to hold the Arcana Duello, a competition that, if won, will grant the winner the title of Papa and any wish they desire. But there is more at stake than just a title: Mondo also decides that the winner will marry his daughter, Felicità. Enraged by this, the strong-willed Felicità decides to enter the competition herself, in order to make her own way in the world. As Felicità battles for her freedom, her competitors battle for her heart.

In the heart of Italy, the Social Welfare Agency rescues young girls from hospital beds and gives them a second chance at life using the latest in cybernetic advancements. With their artificially enhanced bodies, the girls are brainwashed and trained as assassins to carry out the dirty work of the Italian Government. Despite all the modifications, they are still just children at heart, struggling for recognition from those they love, even knowing the love they feel is manufactured. This tragic tale unfolds as these girls grapple with their emotions in an agency that treats them as nothing but ruthless killers.

Brandon Heat and Harry MacDowel, two friends so close they could be called brothers, receive an abrupt and violent reminder one fateful day of how appallingly merciless the world around them can be. Their whole lives before then were simple and easygoing, consisting largely of local brawls, seducing women, and committing petty theft to make a living and pass the time. What they failed to realize is that in this cruel world, happiness is fleeting, and change is inevitable. Enter Millennion, the largest and most infamous mafia syndicate in the area, which accepts Brandon and Harry into their ranks and starts them at the bottom of the food chain. Harry has ambitions to ascend the ranks and one day replace Big Daddy as the supreme leader of Millennion, while Brandon only wishes to support his friend and appease Big Daddy who has taken custody of the woman Brandon loves. Based off the third-person shooter video game under the same name, Gungrave is an epic story of friendship, betrayal, and avarice that spans the course of several years, ultimately tying back to the gripping and foreboding first episode, all the while building up to the story's thrilling conclusion.

Do you know when you are going to die? Michiru Kita does, as she has the ability to see a ring of death on the necks of those around her—and the darker the ring, the closer one is to death. One day, she notices that two boys in her class, Chika Akatsuki and Shito Tachibana, have completely black rings. Seeking to warn them of their impending demise, she stumbles onto their secret: they are already dead, but are kept alive due to a contract with Zombie-Loan, a mysterious loan office. Of course, nothing comes without a price, as the boys must hunt down and kill zombies in order to pay off their debt. And once they learn about Michiru's Shinigami Eyes, they drag her into their crazy world.