In a magical world where humans, demihumans, and oni are heavily at odds with each other, a princess named Saltorine Sally Aldike is on a journey to find a person named Mikoto Kibitsu. Traversing the world, Sally comes across many truths that she had been ignorant of due to her lineage—including the knowledge that the oni possess power potent enough to wipe out humanity. Seemingly blessed with a way to counter the oni's might, Sally has a strange power that manifests itself as a sigil resembling a peach, giving her superhuman abilities capable of defeating powerful oni with ease. Even so, Sally refuses to discriminate between humans, demihumans, and oni as much as possible, believing that peace between the three factions could be attainable one day. On the contrary, Mikoto—who also has the same ability as Sally's but with greater mastery—has a different goal. Mikoto is out to kill and torment all oni in existence, stopping at nothing to fulfill this objective. As Sally and Mikoto continue to cross paths, the power they possess will spell the difference between amicable coexistence and utter annihilation.

A blog disproving the supernatural, co-run by NEET teenager Yuuta Gamon and his enthusiastic best friend Ryouka Narusawa, becomes the catalyst that would bring together a group of people who supposedly have nothing to do with each other. These individuals include high school fortune teller Miyuu Aikawa, who joins Yuuta to work on the blog; realist Sarai Hashigami, who is stunned when tragedy strikes his family; doujin artist Ririka Nishizono, who has an uncanny ability to predict the future with her art; black magic practitioner and local curse expert Aria Kurenaino and her ghostly friend; Shun Moritsuka, a seemingly childish otaku detective; and reporter Touko Sumikaze. As this unlikely group, bound only by the strings of fate, find their way to each other, they are confronted with murder and other events that are shrouded by the presence of the supernatural. They must band together to solve the mysteries interlacing the city and their lives.

In 1864 Japan, a young woman named Chizuru Yukimura is searching for her missing father, Koudou, a doctor by trade whose work often takes him far from home. But with no word from him in months, Chizuru disguises herself as a man and heads to Kyoto in search of him. Attracting the attention of ronin, she tries to hide and ends up witnessing a horrifying sight: the ronin being brutally murdered by crazed white-haired men. In a startling turn of events, members of the Shinsengumi arrive to dispatch the creatures. But Chizuru's safety doesn't last long, as this group of men tie her up and take her back to their headquarters, unsure of whether to let her live or silence her permanently. However, once she reveals the name of her father, the Shinsengumi decide to keep her safe, as they too have been searching for him. But Koudou is more connected to the Shinsengumi than they let on, and soon Chizuru finds herself embroiled in a conflict between the Shinsengumi and their enemies, as well as political tension in Kyoto.

Brandon Heat and Harry MacDowel, two friends so close they could be called brothers, receive an abrupt and violent reminder one fateful day of how appallingly merciless the world around them can be. Their whole lives before then were simple and easygoing, consisting largely of local brawls, seducing women, and committing petty theft to make a living and pass the time. What they failed to realize is that in this cruel world, happiness is fleeting, and change is inevitable. Enter Millennion, the largest and most infamous mafia syndicate in the area, which accepts Brandon and Harry into their ranks and starts them at the bottom of the food chain. Harry has ambitions to ascend the ranks and one day replace Big Daddy as the supreme leader of Millennion, while Brandon only wishes to support his friend and appease Big Daddy who has taken custody of the woman Brandon loves. Based off the third-person shooter video game under the same name, Gungrave is an epic story of friendship, betrayal, and avarice that spans the course of several years, ultimately tying back to the gripping and foreboding first episode, all the while building up to the story's thrilling conclusion.