Ten-year-old Sakura Kinomoto is an ordinary fourth-grade student living in Tomoeda until, one day, she stumbles upon a mysterious book of cards titled The Clow. Pondering over her discovery, she unintentionally causes a magical gust of wind to scatter the cards all over town. The accident awakens the Beast of the Seal—Keroberos, nicknamed Kero—who tells Sakura that she has released the mystical Clow Cards created by the sorcerer Clow Reed. Due to each Card's ability to act independently and their incredible power, Clow had sealed them away. Now that they have been set free, the Cards pose great danger to the world, and it is up to Sakura to put an end to them. Appointing Sakura as the Cardcaptor and granting her the Sealed Key, Kero tasks her with finding and recapturing all the Clow Cards. Alongside her best friend Tomoyo Daidouji, and with Kero's guidance, Sakura must learn to balance her new secret duty with the everyday troubles as she takes flight on her magical adventures as Cardcaptor Sakura.

Childhood friends Tomo Aizawa and Junichirou Jun Kubota do everything together, whether it be training or just enjoying a fun day out. Anyone would think that these two are best friends for life. The only issue is that the tomboyish Tomo is in love with Jun, but he regards her like a brother. At the start of their first year of high school, Tomo confesses her feelings to Jun. However, her rough mannerisms and lack of hesitance to throw a punch do nothing to sway Jun's heart. Realizing that he will remain indifferent to her affections unless she does something about it, Tomo must find a way to knock some sense into Jun and open his eyes to what is right in front of him.

Shizuku Tsukishima is an energetic 14-year-old girl who enjoys reading and writing poetry in her free time. Glancing at the checkout cards of her books one evening, she notices that her library books are frequently checked out by a boy named Seiji Amasawa. Curiosity strikes Shizuku, and she decides to search for the boy who shares her love for literature. Meeting a peculiar cat on the train, Shizuku follows the animal and is eventually led to a quaint antique shop, where she learns about a cat statuette known as The Baron. Taking an interest in the shop, she surprisingly finds Seiji, and the two quickly befriend one another. Shizuku learns while acquainting herself with Seiji that he has a dream that he would like to fulfill, causing her dismay as she remains uncertain of her future and has yet to recognize her talents. However, as her relationship with Seiji grows, Shizuku becomes determined to work toward a goal. Guided by the whispers of her heart and inspiration from The Baron, she resolves to carve out her own potential and dreams.

The Anarchy Sisters, Panty and Stocking, have been kicked out of Heaven for, to put it mildly, misbehaving. Led by a priest named Garterbelt, these angels must buy their way back by exterminating ghosts in Daten City. But this task requires unconventional weapons for these unorthodox angels—they transform their lingerie into weapons to dispatch the spirits. Unfortunately, neither of them take their duties seriously, as they rather spend their time in pursuit of other hobbies: Panty prefers to sleep with anything that walks, and Stocking favors stuffing her face with sweets than hunting ghosts. Follow these two unruly angels as they battle ghosts, an overflow of bodily fluids, and their own tendency to get side-tracked in Panty & Stocking with Garterbelt.