Black Bloods and Red Bloods, vampires and humans. Despite their differences, these two races once fought together in a crusade against a formidable foe. A decade later, the vampire war hero Jirou Mochizuki, known as the Silver Blade, travels with his younger brother Kotarou to the Special Zone—a safe haven where vampires and humans live in harmony. However, their journey is suddenly faced with danger when a conflict erupts between vampire migrants and human forces from the Special Zone. With the rise of a developing conspiracy from an old enemy, Jirou will need the help of his new ally, Mimiko Compromiser Katsuragi, as well as the power of his ancient bloodline to protect what he treasures the most.

The Great Kanto Desert, a sweltering wasteland of nothing but ruins and sand, is all that remains of post-apocalyptic Japan. The once fair population has been left to cling to the inhospitable dunes for survival. At least, that is the case for normal people. For those who have spent a little too long in the Kanto sun, the desert offers a wondrous opportunity to make a name for themselves. One such person is the masked handyman Sunabouzu, or Desert Punk, who has forged a legendary reputation for always finishing his jobs, no matter the nature or cost. Cunning and ruthless, he has become a force of crude destruction to the other desert people. However, the Vixen of the Desert, Junko Asagiri, discovers that Sunabouzu is not without his weaknesses—he is easily swayed by his insatiable lust for large-breasted desert babes. Following their chaotic adventures through the Kanto Desert, Sunabouzu features a bizarre cast of personalities who entertain themselves with senseless violence and perversion in a world long destroyed by their forefathers. And just like them, they have not learned a damn thing.

In its expansion west to gain resources, the Europan Imperial Alliance invades the neutral Principality of Gallia, seeking to take control of its vast Ragnite deposits. Their strategic advantage, technological superiority, and military might make opposition nonexistent, so they steamroll through the border of the sleepy principality with ease. As Imperial forces run through his quiet hometown, Welkin Gunther and his younger sister Isara jump into action, banding with the leader of the local militia to push the occupational forces out of the village. Quickly retreating to the Gallian capital, they are organized into a unit with the remnants of the militia, tasked with assisting in repelling the Imperial presence from the country. Though unfamiliar with war, the newly formed Squad Seven must defend their country from annexation. But as the battle rages on through the streets of Gallia, ancient secrets will bring the team closer than they'd ever anticipated.

With the initiation of the Patrian civil war came the creation of half-beast, half-human soldiers—a development of the outnumbered Northerners in a desperate attempt to counter the overwhelming Southern forces. Able to quickly dominate battlefields and achieve victory with ease, the soldiers' godlike abilities earned them the name Incarnates. However, as the war raged on, the Incarnates encountered a problem involving the beasts inside them that they were unable to rectify by ordinary means. Once the war was over, mysteries and accounts of the Incarnates submitting to the misfortune of their war days surfaced. Aware of the horrors they faced during the war, Special Sergeant Major and former captain of the Incarnates Hank Henriette becomes a Beast Hunter—those who take the lives of Incarnates who have succumbed to the issues they experienced on the battlefields. After witnessing her father, a former Incarnate soldier, meet his end at the hands of one such Beast Hunter, Nancy Schaal Bancroft resolves to hunt the man who took her father's life. However, Nancy's eye-opening encounter with the Beast Hunter influences her to instead seek the reason behind her father's death and the Incarnates' problematic existence in society.