Three months have passed since the Demon King was defeated by a hero. Mankind rejoices over their victory, but dwellers of the demon world do not share the same sentiment. With the loss of their king, they must now hold a tournament to decide who will become his successor. Monitoring the competition is the hot-headed yet powerful Vamirio—one of the Four Heavenly Kings. Among all the participants, she is extremely distrustful of one: Helck, a human hero who claims to hate humanity. As much as she wants to get rid of him, it is impossible due to Helck's incredible strength and popularity. Amidst the competition, Vamirio discovers that humans have vanished from various towns. As a result of this puzzling turn of events, Vamirio grows desperate to reveal Helck's true intentions by carefully crafting a plan to make Helck lose. If she proves to be successful, she might uncover where his loyalty truly lies before the demon world is endangered.

Growing out of the chaos of a global war, the city of Utopia is populated by humans and bioroids (artificial humans). On the surface, everything is harmonious, but tensions lurk. Into this seemingly perfect society comes a survivor of the wars, Deunan Knute, who carries a legacy that will turn out to be of critical importance to the future of humanity. (Source: ANN)

Ten years after the Bubble War, the dichotomy between the rich and the poor in the world becomes more prominent and Japan is no exception. The rich seek to satisfy their desires and derive pleasure for themselves, and Tokyo has materialized into such a city as a result. Saiga, once a war photographer, works for Hibara Ginza in the capitalist state of Tokyo. He infiltrates the Roppongi Club, a secretive base located in the red light district of the city, to collect information about them. However, he was caught in the process and brought forward to a girl called Kagura who was in the midst of a ritual. His contact with Kagura awakens his special ability: the power to make things explode when photographed. In order to unravel the mystery behind the Roppongi Club and Kagura, Saiga begins his solitary battle.

In 1973, following the ruthless six-year-long Lunar War, the hostile alien species known as the BETA—Beings of Extra Terrestrial origin which are Adversary of the human race—invaded Earth, killing billions and decimating Eurasia. While BETA can be destroyed with conventional weapons, their laser-class is able to wipe out entire aircraft fleets, forcing mankind to develop giant combat suits called Tactical Surface Fighters (TSF) to combat them. When the BETA reach Japan in 1998, military school student and TSF pilot—or eishi—Yui Takamura is ordered to defend Kyoto's last line of defense with her fellow classmates. At the cost of countless human lives and the sacrifice of Yui's friends, the Japanese Imperial Army manages to repel the invaders, leaving destruction in its wake. However, this encounter leaves Yui determined to never again allow something like this to occur. Three years later, now a lieutenant, Yui joins the XFJ project, an Alaska-based Japan-American TSF development program. In an international team composed of the uncooperative Japanese-American test pilot Yuuya Bridges and various eishi from countries lost to the BETA, Yui's task is to help develop the new Japanese TSF Shiranui. Amidst political tensions inherited from the Cold War, Muv-Luv Alternative: Total Eclipse follows Yui's delicate mission and Yuuya's journey to overcome the demons of the past that still haunt him.