Hole—a dark, decrepit, and disorderly district where the strong prey on the weak and death is an ordinary occurrence—is all but befitting of the name given to it. A realm separated from law and ethics, it is a testing ground to the magic users who dominate it. As a race occupying the highest rungs of their society, the magic users think of the denizens of Hole as no more than insects. Murdered, mutilated, and made experiments without a second thought, the powerless Hole dwellers litter the halls of Hole's hospital on a daily basis. Possessing free access to and from the cesspool, and with little challenge to their authority, the magic users appear indomitable to most—aside for a few. Caiman, more reptile than man, is one such individual. He hunts them on a heedless quest for answers with only a trusted pair of bayonets and his immunity to magic. Cursed by his appearance and tormented by nightmares, magic users are his only clue to restoring his life to normal. With his biggest obstacle being his stomach, his female companion Nikaidou, who runs the restaurant Hungry Bug, is his greatest ally.

Subaru Mikazuki is a 23-year-old mystery novel author, major introvert, and an awkwardly shy person. He would much rather stay home to read a book than go outside and interact with others. Further exacerbating this life of solitude, his parents tragically died in an accident many years ago, leaving him alone in the world. One day, while giving offerings at his parents' grave, Subaru runs into a small grey and white cat named Haru, which he ends up taking home with him. Subaru, however, has never taken care of anyone else in his life—can he even take care of a cat? Haru is grateful toward Subaru, as he gives her all the food she wants—a luxury for a cat who is used to a rough life on the streets. But she notices that Subaru can't even seem to take care of himself! Will she be okay with this dunce? Doukyonin wa Hiza, Tokidoki, Atama no Ue. tells the story of an unlikely friendship between a human and a cat who try to foster an understanding with each other.

Bayron City, a pioneering metropolis built on a newly discovered energy source, promises every citizen a luxurious and comfortable lifestyle. In reality, young demon exterminator Shuu Ogata's life is far from extravagant. Despite running a private military business, he often struggles to make ends meet due to reckless expenses. Fortunately, Kisara, his demon partner, is more than eager to help Shuu with household matters—albeit a little too forcefully for his comfort. The two work side by side, taking countermeasures against demon hazards, which stand as the biggest threats to the city. With danger lurking in the shadows, Shuu and Kisara strive to grant the town's safety; however, exterminating the possessed comes with a price unbeknownst to others.

One year ago, Sagiri Izumi became step-siblings with Masamune Izumi. But the sudden death of their parents tears their new family apart, resulting in Sagiri becoming a shut-in which cut her off from her brother and society. While caring for what's left of his family, Masamune earns a living as a published light novel author with one small problem: he's never actually met his acclaimed illustrator, Eromanga-sensei, infamous for drawing the most lewd erotica. Through an embarrassing chain of events, he learns that his very own little sister was his partner the whole time! As new characters and challenges appear, Masamune and Sagiri must now face the light novel industry together. Eromanga-Sensei follows the development of their relationship and their struggle to become successful; and as Sagiri slowly grows out of her shell, just how long will she be able to hide her true persona from the rest of the world?