Vampires walk among society, existing as part of its underbelly. They do not require blood to survive, but extreme emotions can immensely increase their bloodlust, turning them into uncontrollable monsters. Tsukasa Taira, a 22-year-old university student, learns of the existence of vampires when her longtime friend reveals himself to be one of them after a tense confrontation with Yuuki Anzai—a human and vampire hybrid. Her friend is arrested, and Tsukasa soon finds herself drawn to Anzai, who reluctantly reciprocates her feelings. However, this unconventional romance may prove too difficult to maintain, as Anzai struggles to contain the part of him that wishes to devour Tsukasa.

It's another regular day, with Houtarou Oreki sitting at home as usual; that is until his sister Tomoe ropes him into working as a lifeguard at the local swimming pool. Upon reaching the pool, Oreki coincidentally meets the other members of the Classics Club. Eru Chitanda notices that a white object that was on a woman's ear a while ago suddenly disappeared, which leaves her curious about the mystery behind it. Hyouka: Motsubeki Mono wa features Oreki and the rest of the Classics Club as they have fun at the pool and solve the mystery that has piqued Chitanda's curiosity.

Thirty-six students find themselves and their school building suddenly adrift in a void-like dimension. When supernatural powers awaken in some of them, a sense of detachment begins to divide the group. Despite the student council's attempts to impose order, they clash with the students possessing special abilities, who rebel against their strict control. This conflict leads them to discover that this world has its own set of rules—and following them is necessary for survival. After one of the students decides to take a leap of faith, the school switches dimensions once again. While they deal with the unique challenges and circumstances that each world presents, the students must unravel the mysterious phenomenon and find a way back home.

World-class medical researcher Kanji Yakutani lost his little sister to a tumor years ago due to ineffective treatment. To honor her legacy, he has dedicated his research to developing new medications for such conditions. But as fate would have it, he overworks himself and passes away at the age of 31, only to be given a second chance at life in another world. When he wakes up, Kanji finds himself in the body of a 10-year-old boy named Falma de Médicis, the son of an esteemed family of medical practitioners in the Sain Fleuve Empire. Bearing the mark of a deity's divine blessing, Falma is capable of performing a unique divine art, allowing him to create and reduce any substance with the knowledge of its chemical properties. After reading through some pharmacology books, Falma realizes that this world is operating on similar medical practices as in ancient times. He also learns that medicine is an exclusive privilege to the nobility, depriving commoners of proper medical care. Using the knowledge from his past life and the divine abilities granted to him, Falma resolves to make medicine available to those who need it—irrespective of class.