Ten years ago, a fairy by the name of Daisy appeared and asked the child Eiji Hoshimiya what his one and only wish was. Although his wish remains a mystery, the consequences were catastrophic. In an event called the Great Destruction, the world started to fall apart as everything collapsed and countless people died. Now, Eiji is a high school student whose only concern is his sick sister. He does not remember what he wished for; all that he remembers is that his wish caused the Great Destruction. In the years since that event, thousands of other people have also received abilities to make their heart's desire come true. These people called Orders are believed to be evil and are hated by the general public. However, some of these Orders are after Eiji's life in vengeance for those that he killed. Will Eiji be able to survive the numerous assassination attempts? And the biggest mystery of all: what did he wish for, and what were his intentions in wishing for something that caused so much desolation?

As a child, Riki Naoe shut himself from the world, thanks to a diagnosis of narcolepsy following the tragic deaths of his parents. However, Riki is saved when, one fateful day, a boy named Kyousuke recruits him into a team who call themselves the Little Busters. Accompanied by Masato, Kengo, and Rin, these misfits spend their childhood fighting evil and enjoying their youth. Years pass, and even in high school, the well-knit teammates remain together. Kyousuke decides to re-ignite the Little Busters by forming a baseball team as it will be his last school year with them. They have a problem though: there aren't enough members! The tables have turned, for it is now Riki's turn to reach out and recruit new friends into the Little Busters, just like Kyousuke had once done for him. Then, an omen surfaces—Rin finds a strange letter attached to her cat, assigning them the duty of uncovering the secret of this world by completing specific tasks. Just what is this secret, and why is it being hidden? It's up to the Little Busters to find out!

For the Takakura family, destiny is an ever-spinning wheel, pointing passionately in their direction with equal tides of joy and sorrow before ticking on to the next wishmaker. With their parents gone, twin brothers Kanba and Shouma live alone with their beloved little sister Himari, whose poor health cannot decline any further. On the day Himari is given permission to temporarily leave the hospital, her brothers take her out to the aquarium to celebrate, where the family's supposed fate is brought forth with her sudden collapse. However, when Himari is inexplicably revived by a penguin hat from the aquarium's souvenir shop, the hand of fate continues to tick faithfully forward. With her miraculous recovery, though, comes a cost: there is a new entity within her body, whose condition for keeping her fate at bay sends the boys on a wild goose chase for the mysterious Penguin Drum. In their search, the boys will have to follow the threads of fate leading from their own shocking past and into the lives of other wishmakers vying for the Penguin Drum, all hoping to land upon their chosen destiny.

Soul Eater NOT! is a spin-off and side story that takes place one year prior to the events of the original Soul Eater. At the Death Weapon Meister Academy, humans born with the power to transform into weapons and those with the power to wield these weapons (Meisters) train to hone their natural talent. The characters of the main series are enrolled in the Especially Advantaged Talent class, where they train to become warriors of justice capable of defeating what threats prey on innocent lives—or even the entire world. Other students at the DWMA are less talented. Members of the Normally Overcome Target class focus less on being warriors of justice and more on controlling their powers so they don't hurt themselves or anyone around them. Tsugumi Harudori, a new halberd-transforming student, meets Meisters Meme Tatane and Anya Hepburn and quickly grows indecisive about which of the two new friends should be her partner. As they learn to use these powers and settle in, their lives as everyday students will be far from normal.