After graduating from a top university with an impressive extracurricular record in the rugby club, Akira Tendou has nailed every step of the way to securing his dream job. On top of that, a beautiful and kind co-worker always brightens his day in the office! Life seems to be going very well for Akira until he slowly realizes that sleepless nights and brutal work are his new reality. Due to three years of mind-numbing labor in an exploitative company, Akira is unable to recognize the tired, unaccomplished person he has become. On track to losing all passion in life like several of his overworked colleagues, Akira finds his saving grace in the most unexpected way possible—the breakout of a zombie apocalypse. With the free time he finally has, Akira decides to complete a bucket list of a hundred things he wants to do before he eventually gets turned into a zombie. Although he is surrounded by the dead, Akira has never felt more alive!

High school student Reki Kyan is passionate about one thing: skateboarding. When night falls, he heads to S, an illegal underground race inside a mine where skaters compete in highly dangerous situations. After a loss that results in his skateboard being destroyed and his arm being broken, Reki is now incapable of practicing at all. While working, Reki runs into his new classmate, Langa Hasegawa, a half-Canadian and half-Japanese boy with no skateboarding experience whatsoever. Langa is in desperate need of money. After they both visit S when tasked by Reki's boss, they get into trouble and are forced into a bet that requires Langa to skate in a race. However, the mysterious transfer student holds a trump card that Reki is unaware of, one which might help him win the race in the most unexpected way.

Despite the immediate challenges following becoming a devil hunter with the Public Safety Bureau, Denji has quickly adapted to his new life and responsibilities. As the chaos of Denji's first ordeal with Public Safety settles down, the elite devil hunter Makima decides to take Denji out on a date. Although the date strengthens his affection for Makima and he swears to not fall in love with anyone else, Denji soon finds himself in a tricky situation when he meets a seemingly innocent cafe worker named Reze. With her forward and flirty demeanor, Reze immediately captures Denji's heart, driving him to frequent the cafe where she works and deepen his relationship with her. However, Denji is completely oblivious to the fact that meeting Reze might have grave consequences beyond simply deciding which woman his heart belongs to.

The student-filled Academy City is at the forefront of scientific advancement and home to the esper development program. The seven Level 5 espers are the most powerful in Academy City, and ranked third among them is middle schooler Mikoto Misaka, an electricity manipulator known as The Railgun. When strange incidents begin occurring throughout the city, she finds each crime to be connected to the elusive Level Upper, a legendary device that allegedly increases the esper level of its user. As the situation escalates, it becomes apparent that there is more to the Level Upper than meets the eye, and that Academy City may be a far more twisted place than the glamorous utopia it appears to be. Toaru Kagaku no Railgun focuses on Mikoto and her friends—and the dangerous situations they find themselves in—as they get caught up in the matter of the Level Upper. As Mikoto says, There's never a dull moment in this city.