Since childhood, Aoba Suzukaze has loved the Fairies Story game series, particularly the character designs. So when she graduates from high school, it is no surprise that she applies to work at Eagle Jump, the company responsible for making her favorite video game. On her first day, she is excited to learn that she will be working on a new installment to the series: Fairies Story 3—and even more so under Kou Yagami, the lead character designer. In their department are people who share the same passion for games. There is Yun Iijima, whose specialty is designing monsters; the shy Hifumi Takimoto, who prefers to communicate through instant messaging; Hajime Shinoda, an animation team member with an impressive figurine collection; Rin Tooyama, the orderly art director; Shizuku Hazuki, the game director who brings her cat to work; and Umiko Ahagon, the short-tempered head programmer. New Game! follows Aoba and the others on their adventure through the ups and downs of game making, from making the perfect character design to fixing all the errors that will inevitably accumulate in the process.

Throughout history, humans have been at odds with Beastmen—a species capable of changing shape due to their genetic Beast Factor. Because of this conflict, Beastmen have been forced into hiding. Anima City serves as a safe haven for these oppressed individuals to live free from human interference. During a festival celebrating the town's 10th anniversary, Michiru Kagemori, a human who suddenly turned into a tanuki, finds that Anima City is a far cry from paradise. After witnessing an explosion in the square, she is confronted by Shirou Ogami, a seemingly indestructible wolf and sworn protector of all Beastmen. As they pursue the criminals behind the bombing, the two discover that Michiru is anything but an ordinary Beastman, and look to investigate her mysterious past and uncanny abilities. Could she turn out to be the missing link between Humans and Beastmen?

On the hot summer day of August 14, Shintarou Kisaragi is forced to leave his room for the first time in two years. While arguing with the cyber girl Ene who lives in his computer, Shintarou Kisaragi accidentally spills soda all over his keyboard. Though they try to find a replacement online, most stores are closed due to the Obon festival, leaving them with no other choice but to visit the local department store. Venturing outside makes Shintarou extremely anxious, but the thought of living without his computer is even worse. It's just his luck that on the day he finally goes out, he's caught in a terrifying hostage situation. Luckily, a group of teenagers with mysterious eye powers, who call themselves the Mekakushi Dan, assist Shintarou in resolving the situation. As a result, he is forced to join their group, along with Ene. Their abilities seem to be like pieces of a puzzle, connecting one another, and as each member's past is unveiled, the secret that ties them together is slowly brought to light.

In Ikebukuro, the lives of its citizens continue intertwining with each other as if their fates are predestined. Mikado Ryuugamine is now one step closer to his goal of living an exciting life, and in turn, delves deeper into the darker side of Ikebukuro. After gaining absolute control over a former rival, he uses his newfound power as he pleases, purging the Dollars from the inside to mold it into the ideal organization. This proves to be as challenging as it sounds as Mikado must now deal with unwanted outside interference, most notably a re-emerging and dearly missed friend. Meanwhile, Izaya Orihara still has some schemes up his sleeve, although a rival information exchange center has proven to be quite the hindrance, lurking within everyone's favorite downtown district. Undoubtedly, sooner or later, chaos will strike again.